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1

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Dose Linearity and Proportionality

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 700 KB

english, 2018

2

PM101: A cyclodextrin-based intravenous formulation of amiodarone devoid of adverse hemodynamic effects

Daniel J. Cushing, Peter R. Kowey, Warren D. Cooper, Bill W. Massey, Michael R. Gralinski, Raymond J. Lipicky

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 296 KB

english, 2009

3

Characterization of binding, functional activity and contractile responses of the selective 5‐HT 1F receptor agonist lasmiditan

Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B.,

Journal:

British Journal of Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.29 MB

english, 2019

4

Selective inhibition of the alternative complement pathway by sCR1[desLHR-a]protects the rabbit isolated heart from human complement-mediated damage

Michael R. Gralinski, Bridget C. Wiater, Amy N. Assenmacher, Benedict R. Lucchesi

Journal:

Immunopharmacology

Year:

1996

Language:

english

File:

PDF, 828 KB

english, 1996

5

Comparison of the Cardiac Electrophysiology and General Toxicology of Two Formulations of Intravenous Amiodarone in Dogs

Daniel J. Cushing, Warren D. Cooper, Michael R. Gralinski, Raymond J. Lipicky, Peter J. Kudenchuk, Peter R. Kowey

Journal:

Cardiovascular Toxicology

Year:

2009

Language:

english

File:

PDF, 290 KB

english, 2009

6

The hypotensive effect of intravenous amiodarone is sustained throughout the maintenance infusion period

Daniel J Cushing, Warren D Cooper, Michael R Gralinski, Raymond J Lipicky

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2010

Language:

english

File:

PDF, 277 KB

english, 2010

7

C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats

David A. Zopf, Liomar A.A. das Neves, Kristen J. Nikula, Jinbao Huang, Peter B. Senese, Michael R. Gralinski

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

8

ANESTHETIZED DOG MODEL FOR THE ACUTE STUDY OF PHARMACEUTICALS

Michael R. Gralinski, Jinbao H. Huang

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

9

A model of sustainable atrial fibrillation in the chronic conscious dog

Michael R. Gralinski, Douglas L. Janssen, Hongjian Wang, Melissa D. Fisher, Peter B. Senese

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

10

Pulmonary arterial hypertension induced by low oxygen environment in the presence of VEGF receptor antagonism

Peter B. Senese, Douglas L. Janssen, Melissa D. Fisher, Jinbao B. Huang, Michael R. Gralinski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

11

The assessment of potential for QT interval prolongation with new pharmaceuticals: Impact on drug development

Michael R Gralinski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2000

Language:

english

File:

PDF, 149 KB

english, 2000

12

Localization of cyclooxygenase isozymes in cardiovascular tissues of dogs treated with naproxen

Kristina M. Stanfield, K.Nasir Khan, Michael R. Gralinski

Journal:

Veterinary Immunology and Immunopathology

Year:

2001

Language:

english

File:

PDF, 685 KB

english, 2001

13

Effects of flecainide and dronedarone on atrial and ventricular effective refractory period in the dog with pacing induced atrial remodeling

Michael R. Gralinski, Peter B. Senese, Jinbao B. Huang, Hongjian O. Wang, James R. Buening, Douglas L. Janssen

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

14

TCT-138 Veropaque, A Novel Contrast Formulation, Mitigates Contrast Induced Acute Kidney Injury

Sangita Biswas, Elizabeth Rowe, Gerold Mosher, Lovella Insisienmay, Marlies Ozias, Michael Gralinski, Vernon Rowe

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 88 KB

english, 2012

15

The Dog's Role in the Preclinical Assessment of QT Interval Prolongation

Gralinski, Michael

Journal:

Toxicologic Pathology

Year:

2003

Language:

english

File:

PDF, 68 KB

english, 2003

16

Effect of Ranolazine on Infarct Size in a Canine Model of Regional Myocardial Ischemia/Reperfusion

Black, Shawn C., Gralinski, Michael R., McCormack, James G., Driscoll, Edward M., Lucchesi, Benedict R.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1994

File:

PDF, 4.41 MB

1994

17

Preclinical Studies of a Kidney Safe Iodinated Contrast Agent

Rowe, Elizabeth S., Rowe, Vernon D., Biswas, Sangita, Mosher, Gerold, Insisienmay, Lovella, Ozias, Marlies K., Gralinski, Michael R., Hunter, John, Barnett, James S.

Journal:

Journal of Neuroimaging

Year:

2016

Language:

english

File:

PDF, 912 KB

english, 2016

18

Treatment for established hypoxia-semaxanib induced pulmonary arterial hypertension in rats: Riociguat and sildenafil improve pulmonary hemodynamics and right ventricular hypertrophy using a disease intervention strategy

Hock, Franz, Huang, Jinbao, Janssen, Douglas, Zammit, Melissa, Neves, Liomar, Senese, Peter, Gralinski, Michael

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 64 KB

english, 2016

19

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Evaluation: Gastroenterology

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 344 KB

english, 2017

20

What is the Ideal Animal Model for Idiopathic Pulmonary Hypertension?

Bruse, Kristy, Gralinski, Michael

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 69 KB

english, 2017

21

The Effect of Anesthetic on Hemodynamics Measurements in a Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension

Huang, Jinbao, Wang, Hongjian, Neves, Liomar, Tiniakova, Olga, Senese, Peter, Gralinski, Michael

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 67 KB

english, 2017

22

Ferric Chloride-Induced Arterial Thrombosis Model in Pre-Clinical Drug Development

Neves, Liomar, Tiniakova, Olga, Wang, Hongjian, Huang, Jinbao, Senese, Peter, Gralinski, Michael

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 48 KB

english, 2017

23

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Clinical Pharmacology of Tinnitus: Design and Evaluation

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 862 KB

english, 2017

24

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Evaluation: Herbal Medicine

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 356 KB

english, 2017

25

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Medical Devices: Definition and Clinical Testing

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 250 KB

english, 2018

26

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamics in Clinical Pharmacology

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 1.73 MB

english, 2018

27

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Dose Finding in Single Dose Studies by Allometric Scaling

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 148 KB

english, 2018

28

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Evaluation: Endocrinology

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 156 KB

english, 2017

29

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || PK/PD Approaches

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 547 KB

english, 2018

30

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || In Vitro/In Vivo Correlation for Drug-Drug Interactions

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 461 KB

english, 2018

31

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacological Therapy in Inborn Errors of Metabolism

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 436 KB

english, 2018

32

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Clinical Aspects in Sleep Disorders and Apnea

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 678 KB

english, 2018

33

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Effects of Food Intake

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 122 KB

english, 2018

34

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Space Pharmacology: How Space Affects Pharmacology

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 1.02 MB

english, 2018

35

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Absolute and Relative Bioavailability

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 140 KB

english, 2018

36

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || General Principles of Pharmacovigilance in Clinical Development

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 203 KB

english, 2018

37

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Drug–Drug Interaction Studies

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 283 KB

english, 2017

38

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Evaluation: CNS Methodologies

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 157 KB

english, 2018

39

Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart

Gralinski, Michael R., Chi, Liguo, Park, James L., Friedrichs, Gregory S., Tanhehco, Elaine J., McCormack, James G., Lucchesi, Benedict R.

Journal:

Journal of Cardiovascular Pharmacology and Therapeutics

Year:

1996

Language:

english

File:

PDF, 615 KB

english, 1996

40

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Noninvasive Methodology (NMR)

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 338 KB

english, 2018

41

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Methodologies of PD Assessment: Scales

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 347 KB

english, 2018

42

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Future of Regulatory Safety Assessments

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 280 KB

english, 2018

43

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Relevance of Transporters in Clinical Studies

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 651 KB

english, 2018

44

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Clinical Studies in Infants (Pediatric Pharmacology)

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 287 KB

english, 2017

45

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || The Human ADME Study

Hock, Franz J., Gralinski, Michael R.

Year:

2017

Language:

english

File:

PDF, 1.22 MB

english, 2017

46

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacokinetic Aspects of Multiple Dose Studies

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 336 KB

english, 2018

47

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Absolute and Relative Bioavailability

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 142 KB

english, 2018

48

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Evaluation: Drug Dependency and Addiction

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 371 KB

english, 2018

49

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Clinical Quality Management System

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 117 KB

english, 2018

50

Drug Discovery and Evaluation: Methods in Clinical Pharmacology || Pharmacodynamic Drug–Drug Interactions

Hock, Franz J., Gralinski, Michael R.

Year:

2018

Language:

english

File:

PDF, 417 KB

english, 2018